How long is Xdemvy used?

The labeled course is twice daily for 6 weeks, unless your doctor gives different instructions.

Can I stop lid cleaning after Xdemvy?

Do not stop your lid plan unless your doctor says so. Many people still need lid hygiene for oil, crust, or rosacea.

Does Xdemvy treat dry eye?

It treats Demodex blepharitis. Dry eye may still need tears, warm compresses, or other treatment.

Can I wear contacts during treatment?

Ask your doctor. Contact lens timing matters because drops and lenses can irritate the eye.

Treatment

Xdemvy / Lotilaner

Also known as Xdemvy, Lotilaner Eye Drops, Demodex Blepharitis Drops, Mite Eyelid Treatment, Collarette Treatment

Updated May 16, 2026·For educational purposes only. Not a substitute for medical advice. See our terms.

Bottom Line

Xdemvy is a prescription lotilaner eye drop for Demodex blepharitis. It is used twice daily for 6 weeks to target mites at the lash base.

Demodex blepharitis is eyelid inflammation linked to Demodex mites. The classic sign is cylinder-shaped collarettes at the base of the lashes ¹.

Lotilaner ophthalmic solution targets Demodex mites. The prescribing information lists one drop in each eye twice daily, about 12 hours apart, for 6 weeks ².

In randomized trials, lotilaner cleared more of the lash-base crusts and killed more mites than inactive (placebo) drops ³.

How It Works

Lotilaner is used to kill Demodex mites on the eyelids. Demodex blepharitis often shows cylinder-shaped collarettes at the lash base ¹.

The treatment does not replace a diagnosis. Your doctor should confirm collarettes or mite-related blepharitis before prescribing it.

Side Effects

The prescribing information lists instillation-site stinging and burning as the most common adverse reaction. It also warns not to touch the dropper tip to the eye, fingers, or any surface ².

Call your doctor for severe pain, swelling, discharge, allergy symptoms, or a vision drop.

Cost and Insurance

Xdemvy cost varies by plan, pharmacy, deductible, and prior authorization rules. Some insurers ask for proof of Demodex blepharitis before approval.

Ask your clinic what documentation your plan needs. Ask the pharmacy about coupons or patient support if the copay is high.

Common Questions About Xdemvy

An eye doctor looks for collarettes at the base of your lashes. Symptoms alone cannot prove mite-related blepharitis.

Next Steps

1Ask your eye doctor to confirm collarettes before starting treatment.
2Use the drop twice daily for the full course unless told to stop.
3Avoid touching the bottle tip to your eye, lashes, fingers, or counter.
4Follow your doctor's contact lens instructions during treatment.
5Book a follow-up visit to check collarettes and symptoms.

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